WHAT IS AN ESTER?
Esters are molecular chains derived from carboxylic acids and are usually comprised of a hydrocarbon group (hydrogen and carbon atoms). Esters are usually coupled to the 17-beta hydroxyl group of the parent molecule and increase the active life of the steroid.
This alteration decreases the steroids water solubility (and conversely, increases oil solubility) meaning it isn’t as easily absorbed into the body’s circulatory system. Once injected, the steroid enters the muscle and then beings to slowly circulate around the body. The larger the molecular chain (the more atoms that are included in the chain), the more oil soluble the steroid is which increase the time it takes for the administered dosage to be released.
Once the steroid compound has begun to enter circulation, the body’s enzymes work to remove the ester, freeing the parent hormone so it can exert its activity. This takes a varying amount of time which depends on which ester the hormone is attached to.
Retarding the steroids release is extremely beneficial, as a free version of the hormone would not remain active nor exert its effect for long (typically hours) and frequent administration would be required in order to see any benefit. As you will see below, there are a huge number of esters, each providing a different release time.
It’s commonly cited that esters don’t affect or change the activity of the parent hormone in any way and only slow the release. However this is not strictly the case, and it’s been proven that longer esters are more anabolic than shorter esters. As the length of time a steroid is in your system increases, the amount of nitrogen retained is also increased, thereby increasing the overall anabolic effect.
In contrast, steroids with short esters causes a higher peak plasma level than a long ester does, meaning a higher level of the steroid can be obtained in the blood. A short ester, means you will get more bang for your buck.
These two distinct advantages demonstrate why it is advantageous to run both long and short esters during a cycle, both to obtain the highest level of anabolism possible, and also to provide peak plasma concentration. It also demonstrates why mixes and blends are superior to single ester steroid cycles.
HALF-LIFE OF ESTERS